Alpha-Toxin Promotes Staphylococcus aureus Mucosal Biofilm Formation
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چکیده
منابع مشابه
Alpha-Toxin Promotes Staphylococcus aureus Mucosal Biofilm Formation
Staphylococcus aureus causes many diseases in humans, ranging from mild skin infections to serious, life-threatening, superantigen-mediated Toxic Shock Syndrome (TSS). S. aureus may be asymptomatically carried in the anterior nares or vagina or on the skin, serving as a reservoir for infection. Pulsed-field gel electrophoresis clonal type USA200 is the most widely disseminated colonizer and the...
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Staphylococcus aureus is a common pathogen associated with nosocomial infections. It can persist in clinical settings and gain increased resistance to antimicrobial agents through biofilm formation. We have found that alpha-toxin, a secreted, multimeric, hemolytic toxin encoded by the hla gene, plays an integral role in biofilm formation. The hla mutant was unable to fully colonize plastic surf...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2012
ISSN: 2235-2988
DOI: 10.3389/fcimb.2012.00064